Cicatricial pemphigoid
Evidence: Antibody
Names
Cicatricial pemphigoid
MMP
Mucous membrane pemphigoid
Ocular pemphigoid
Scarring pemphigoid
Description
Cicatricial pemphigoid is a rare autoimmune disease, discovered in 2002, that causes blistering of the mucous membranes. This blistering is due to autoantibodies binding to anchoring filaments of the epidermis. A common mucous membrane that is affected is the conjunctiva of the eye. Other areas that can be affected include the skin, nose, mouth, and genitals.
Cicatricial pemphigoid is usually not chronic, and most patients symptoms disappear within 3 years.
Patient Groups
Bloggers
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Prevalence
Incidence, US cases: 6,000 - 40,000 annually [Hübner 2016] Most cases last 3 years or less.
Typical Age of onset
60-70 years
Symptoms
Eye sensitivity
Conjunctivitis
Lesions that lead to scar tissue
Nutritional deficiencies and weight loss
Blisters
Nose bleeds
Pain passing urine
Adhesions causing narrowing of the vaginal opening
