Autoimmune polyendocrine syndrome type 3
Evidence: Antibody
Names
Autoimmune polyendocrine syndrome type 3
Autoimmune polyglandular syndrome type III
PAS 3
PAS III
Polyglandular autoimmune syndrome, type 3
Polyglandular deficiency syndrome type 3
Description
Autoimmune polyglandular syndrome (APS) type 3 is an autoimmune condition that affects the body's endocrine glands. This syndrome arises from the failure of these glands to produce hormones and is characterized by autoimmune thyroiditis along with another organ-specific autoimmune disease. The additional autoimmune diseases may include diabetes mellitus, pernicious anemia, vitiligo, alopecia, myasthenia gravis, and Sjogren’s syndrome.
There are three subtypes of autoimmune polyglandular syndrome type 3: APS3A: Autoimmune thyroiditis with immune-mediated diabetes mellitus (IMDM), APS3B: Autoimmune thyroiditis with pernicious anemia, and APS3C: Autoimmune thyroiditis with vitiligo and/or alopecia and/or other organ-specific autoimmune diseases.
The exact cause of APS type 3 is unknown, but it is believed to involve an autoimmune response, influenced by environmental factors (such as viral infections) and genetic factors (such as variations in the HLA II genes).
Patient Groups
None
Bloggers
None
Prevalence
Rare (no published data)
Typical Age of onset
Can occur at any age, but typically affects middle age women [NORD].
Symptoms
Depend on specific diseases:
Skin pigmentation loss
Alopecia
Other: fatigue, puffy face, enlarged thyroid, puffiness and swelling around the eyes, drooping eyelids, weakness, extreme hunger, blurry vision, weight loss, shortness of breath
