Description

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of diseases characterized by destruction and inflammation of small vessels. The clinical signs vary and affect several organs, such as the kidney, stomach, intestine, and lung. Skin lesions, such as purpura and urticaria, result when blood from small vessels leaks under the skin. AAV occurs when neutrophils attack small and medium vessels of the body. The underlying reason for this remains unclear.

Patient Groups

Vasculitis Foundation

Bloggers

We have not found any current bloggers for this disease. If you are one, or know someone who is, please contact us.

Prevalence

US Cases: 15,000 - 60,000 [Berti 2017]

Typical Age of onset

Varies depending on type of vasculitis; estimates range from 15 to 70 years old. (No data referenced.)

Symptoms

These symptoms vary depending on the type of vasculitis:

• Fever

• Headache

• Fatigue

• Weight loss

• General aches and pains

• Night sweats

• Rash

• Numbness

• Weakness

Source: Mayo Clinic

Resources

Link to Clinical Trials

Link to Scientific Publications

References

Genetic and Rare Diseases Information Center (GARD)
Mayo Clinic
American Academy of Family Physicians